General and Molecular Pharmacology: Principles of Drug Action

General and Molecular Pharmacology: Principles of Drug Action by Francesco Clementi and Guido Fumagalli
English | 2015 | ISBN: 1118768574 | 786 pages | PDF | 64,2 MB

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.

• Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students

• Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs

• Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties

• Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development

• Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, all figures and tables from the book, and Power Point slides

Applying Genomic and Proteomic Microarray Technology in Drug Discovery (2nd Edition)

Applying Genomic and Proteomic Microarray Technology in Drug Discovery (2nd Edition) By Robert S. Matson
2013 | 322 Pages | ISBN: 1439855633 | PDF | 20 MB

Microarrays play an increasingly significant role in drug discovery. The commercial landscape has changed dramatically over the past few years and researchers have made great advancements with regard to construction and use. Now in its second edition, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications.

Unique to this edition is a new chapter on multiplex assays that examines the development and applications of arrays across diverse platforms. It discusses applications for qPCR, multiplex lateral flow, and multiplex bead assays. It also presents platform-to-platform comparisons.
Microarrays remain an invaluable tool for omics-based research not only in drug discovery, but in the life sciences, in clinical research, and for diagnostic applications worldwide. This volume presents the current state of the art on the utility of this technology to solve a host of important biological problems.